Changes in Thresholds of Electrically Evoked Phosphene and Electrical Lability of the Optic Nerve in the Ground Station Crew in the International Experiment SIRIUS 20/21

In the ground sealed station crew, during 8 months international experiment SIRIUS 20/21 simulating an interplanetary flight, electrically induced phosphene (EIP) thresholds, which reflected electrical sensitivity (ES) of retina, and optic nerve. ES&L was assessed using “ESOM” device (“Neuron”, Ufa, Russia) once a month, twice day (morning/evening), under mesopic conditions. An increase in ES other patterns changes parameters period isolation were established, reflecting adaptation crew to conditions reaction visual system physical psycho-emotional stress. Further study thresholds EIP L nerve experiments increasing duration will make it possible determine biomarkers that differentiate individual adaptive astronauts from dysfunction retina real space flight The showed greater resistance experimental than retina. results suggest determination test can become express on board ISS assess functional state papillomacular bundle fibers, risk developing or diagnosing SANS (flight-associated neuro-ocular syndrome) long-term missions.